闻晓波

男，博士，教授；研究生导师；海南省拔尖人才；

海南地方猪产业技术体系岗位科学家

邮箱：xiaobo_wen@hainanu.edu.cn

通讯地址：海南省海口市美兰区人民大道58号，邮政编码：570228

研究领域

动物传染病的预防与控制

教育背景

2003年9月-2006年6月 中国农业科学院哈尔滨兽医研究所 预防兽医专业 博士

2000年9月-2003年6月 黑龙江八一农垦大学 预防兽医专业 硕士

1996年9月-2000年6月 黑龙江八一农垦大学 动物医学专业 学士

工作经历

2006年7月- 2008年8月 黑龙江八一农垦大学动物科技学院 讲师

2008年9月- 2008年12月 黑龙江八一农垦大学动物科技学院 副教授

2009年1月- 2012年6月 美国国立卫生研究院（NIH） 博士后

2012年7月- 2017年9月 黑龙江八一农垦大学动物科技学院 副教授

2017年9月-2019年10月 黑龙江八一农垦大学动物科技学院 教授

2019年11月-海南大学动物科技学院 教授

讲授课程：

本科：兽医传染病学、兽医微生物学、兽医生物制品学、兽医学概论

研究生：兽医临床病例分析与研讨专题、文献解析专题

科研项目

1.海南省自然科学基金项目，猪塞内卡病毒3C蛋白调控IFN信号转导通路的关键结构域及其作用机制、2020/12-2023/12、7万元，在研，主持。

2.海南大学科研启动项目，猪塞内卡病毒调控IFN信号转导通路及病毒致弱机制研究、2020/5-2025/5、100万元，在研，主持。

3.国家自然科学基金青年项目， 牛UK株轮状病毒拮抗Ⅰ型IFN信号转导通路机制的研究、2013/01-2015/12、24万元、已结题、主持。

4.黑龙江省科学基金面上项目，异源宿主细胞内牛轮状病毒NSP1蛋白调控IFN免疫应答机制、2015/7-2018/7、10万元、已结题、主持。

5.博士后研究人员落户黑龙江科研启动资助项目，Caco-2细胞网格蛋白表达对轮状病毒侵入的影响、2014/1-2016/12、5万元、已结题、主持。

发表论文

[1]Zhao S M, Cui H Q, Hu Z R, Du L, Ran X H,Wen X B*. Senecavirus A Enhances Its Adaptive Evolution via Synonymous Codon Bias Evolution [J]. Viruses-Basel, 2022, 14(5): 1055.

[2]Zhang X, Cui K,Wen X, Li L, Yu X, Li B, Lin H, He H, Wang F. The Association between Gut Microbiome Diversity and Composition and Heat Tolerance in Cattle [J]. Microorganisms, 2022, 10(8): 1672.

[3]Lv Q, Ran X, Qiu H, Zhao S, Hu Z, Wang J, Ni H,Wen X*. Seroprevalence of pullorum disease in chicken across mainland China from 1982 to 2020: A systematic review and meta-analysis [J]. Res Vet Sci, 2022, 152: 156-66.

[4]Yang Y, Teng Z, Lu Y, Luo X, Mu S, Ru J, Zhao X, Guo H, Ran X,Wen X*, Sun S*. Enhanced immunogenicity of foot and mouth disease DNA vaccine delivered by PLGA nanoparticles combined with cytokine adjuvants [J]. Res Vet Sci, 2021, 136: 89-96.

[5]Gong Q L, Chen Y, Tian T,Wen X, Li D, Song Y H, Wang Q, Du R, Zhang X X. Prevalence of bovine tuberculosis in dairy cattle in China during 2010-2019: A systematic review and meta-analysis [J]. PLoS Negl Trop Dis, 2021, 15(6): e0009502.

[6]Dong H, Lu Y L, Zhang Y, Mu S Y, Wang N, Du P, Zhi X Y,Wen X B, Wang X X, Sun S Q, Zhang Y M, Guo H C. A Heat-Induced Mutation on VP1 of Foot-and-Mouth Disease Virus Serotype O Enhanced Capsid Stability and Immunogenicity [J]. J Virol, 2021, 95(16): e0017721.

[7]Wen X, Tong X, Wang M, Wang J, Ni H, Ran X. Protective immunity following vaccination with a recombinant multiple-epitope protein of bovine herpesvirus type I in a rabbit model [J]. Appl Microbiol Biotechnol, 2020, 104: 3011-23.

[8]Ni H, Jia X X, Wang J, Ran X,Wen X*. Mapping a highly conserved linear neutralizing epitope at the N-terminus of the gD glycoprotein of bovine herpesvirus type I using a monoclonal antibody [J]. Microb Pathog, 2020, 138: 103815.

[9]Mu S, Abdullah S W, Zhang Y, Han S, Guo H, Li M, Dong H, Xu J, Teng Z, Wen X, Sun S*. Development of a novel SYBR green I-based quantitative RT-PCR assay for Senecavirus A detection in clinical samples of pigs [J]. Mol Cell Probes, 2020, 53: 101643.

[10] Lu Y, Dong H, Li J, Li L, Wang M, Liu H, Teng Z, Zhang Y, Jin Y, Guo H, Yang Y,Wen X*, Sun S*. Enhanced Protective Immune Response of Foot-and-mouth Disease Vaccine through DNA-loaded Virus-like Particles [J]. Microb Pathog, 2020, 143: 104130.

[11]Wang X, Bi Y, Ran X, Tong X, Ni H,Wen X*. Mapping a highly conserved linear neutralizing epitope on gD glycoprotein of bovine herpesvirus type I using a monoclonal antibody [J]. J Vet Med Sci, 2019, 81(5): 780-6.

[12] Ran X, Yang Z, Bai M, Zhang Y, Wen X, Guo H, Sun S. Development and validation of a competitive ELISA based on bacterium-original virus-like particles of serotype O foot-and-mouth disease virus for detecting serum antibodies [J]. Appl Microbiol Biotechnol, 2019, 103(7): 3015-24.

[13] Ran X, Meng X Z, Geng H L, Chang C, Chen X, Wen X, Ni H. Generation of porcine Pasteurella multocida ghost vaccine and examination of its immunogenicity against virulent challenge in mice [J]. Microb Pathog, 2019, 132: 208-14.

[14] Ran X, Cheng J, Wang M, Chen X, Wang H, Ge Y, Ni H, Zhang X X*,Wen X*. Brucellosis seroprevalence in dairy cattle in China during 2008-2018: A systematic review and meta-analysis [J]. Acta Trop, 2019, 189: 117-23.

[15]Ran X, Chen X, Wang S, Chang C, Wen X, Zhai J, Ni H. Preparation of porcine enterotoxigenic Escherichia coli (ETEC) ghosts and immunogenic analysis in a mouse model [J]. Microb Pathog, 2019, 126: 224-30.

[16] Ran X, Chen X, Ma L, Wen X, Zhai J, Wang M, Tong X, Hou G, Ni H. A systematic review and meta-analysis of the epidemiology of bovine viral diarrhea virus (BVDV) infection in dairy cattle in China [J]. Acta Trop, 2019, 190: 296-303.

[17]Ran X, Yang Z, Shao G, Wen X, Liu S, Ni H. Avian Salmonella enteritidis serovar Enteritidis with ClpP deletion is attenuated and highly immunogenic in chickens [J]. Turkish Journal of Veterinary and Animal Sciences, 2018, 42(4): 269-76.

[18]Ran X, Chen X, Wang M, Cheng J, Ni H, Zhang X X*,Wen X*. Brucellosis seroprevalence in ovine and caprine flocks in China during 2000-2018: a systematic review and meta-analysis [J]. BMC Vet Res, 2018, 14(1): 393.

[19] Wen X, Sun J, Zhang Y, Cao S, Ran X, Ni H. Identification and genetic characterization of bovine parainfluenzavirus type 3 genotype c strain isolated from cattle in western China [J]. Turkish Journal of Veterinary and Animal Sciences, 2017, 41: 180-6.

[20] Wen X B, Jiang H T, Zhang Y L, Lang X Y, Liu J, Ni H B. Rapid and Sensitive Diagnosis of Cattle Anaplasmosis by Loop-Mediated Isothermal Amplification (LAMP) [J]. Pakistan Veterinary Journal, 2016, 36(2): 174-8.

[21] Wen X, Wei X, Ran X*, Ni H, Cao S, Zhang Y. Immunogenicity of porcine P[6], P[7]-specific truncated VP8* rotavirus subunit vaccines with a tetanus toxoid universal T cell epitope [J]. Vaccine, 2015, 33(36): 4533-9.

[22] Wen X, Cao D, Jones R W, Hoshino Y, Yuan L. Tandem truncated rotavirus VP8* subunit protein with T cell epitope as non-replicating parenteral vaccine is highly immunogenic [J]. Human vaccines & immunotherapeutics, 2015, 11(10): 2483-9.

[23]Ma Y, Wen X, Hoshino Y, Yuan L*. Cloning and nucleotide sequence analyses of 11 genome segments of two American and one British equine rotavirus strains [J]. Veterinary microbiology, 2015, 176(1-2): 172-8.

[24] Wen X, Wen K, Cao D, Li G, Jones R W, Li J, Szu S, Hoshino Y, Yuan L*. Inclusion of a universal tetanus toxoid CD4(+) T cell epitope P2 significantly enhanced the immunogenicity of recombinant rotavirus DeltaVP8* subunit parenteral vaccines [J]. Vaccine, 2014, 32(35): 4420-7.

[25] Wen X, Cao D, Jones R W, Li J, Szu S, Hoshino Y*. Construction and characterization of human rotavirus recombinant VP8* subunit parenteral vaccine candidates [J]. Vaccine, 2012, 30(43): 6121-6.

[26]Long-Croal L M, Wen X, Ostlund E N, Hoshino Y*. Concentration of acrylamide in a polyacrylamide gel affects VP4 gene coding assignment of group A equine rotavirus strains with P[12] specificity [J]. Virology journal, 2010, 7: 136.