陈云

男，博士，副教授，博（硕）士生导师。

邮 箱：ychen@hainanu.edu.cn

研究方向

免疫调节、生长性能调控、肠道健康

硕士生招生专业

畜牧学、兽医专硕

教育背景

2012年9月-2017年6月 南京农业大学 博士

2008年9月-2012年7月 南京农业大学 学士

工作经历

2021年1月-至今 海南大学动物科技学院 副教授

2017年7月-2020年12月 海南大学动物科技学院 讲师

讲授课程

《中兽医学》、《分子生物学》等

科研项目

1、海南砂仁多糖影响仔猪小肠绒毛形态的作用与机制研究，国家自然科学基金地区基金项目，35万，2022.1-2025.12，主持。

2、海南砂仁多糖-镁调控文昌鸡生长性能的关键技术研究，海南省重点研发计划，30万，2022.3-2024.3，主持。

3、益智仁多糖抗猪流行性腹泻病毒的作用与机制研究，国家自然科学基金青年基金项目，26万，2019.1-2021.12，主持。

4、鸡传染性法氏囊病VP2亚单位疫苗的南药多糖PLGA免疫佐剂研究，海南省重点研发计划，32万，2019.4-2021.4，主持。

5、基于淋巴细胞和巨噬细胞的益智仁多糖增强免疫活性研究，海南省自然科学基金青年基金项目，5万，2018.1-2019.12，主持。

6、广藿香多糖抗猪流行性腹泻病毒的作用研究，海南大学E类人才科研启动经费，30万，2018.1-2022.12，主持。

教研项目

1、速记歌诀在中兽医学教学中的应用，海南大学教育教学改革研究项目，1万，2019.1-2021.12，主持。

出版著作

《中兽医学》（副主编），（中国林业出版社，2019）

《执业兽医资格考试基础科目速记歌诀》（副主编），（中国农业出版社，2019）

发表文章（第一/通讯作者）

1.Haowen Wu, Huricha Chen, Jiaguo Liu, Zengyang Xing, Jiahao Ni, Ling Teng,Yun Chen*. Amomum longiligulare polysaccharide 1- PLGA nanoparticle promotes the immune activities of T lymphocytes and dendritic cells [J]. International Immunopharmacology, 2022 112, 109204.

2.Jiahao Ni, Huricha Chen, Chenglong Zhang, Qiyuan Luo, Yao Qin, Yuhui Yang,Yun Chen*. Characterization of Alpinia officinarum Hance polysaccharide and its immune modulatory activity in mice [J]. Food & Function, 2022, 13, 2228-2237.

3.Ruigang Zhou, Ling Teng, Yongjian Zhu , Chenglong Zhang , Yuhui Yang ,Yun Chen*. Preparation of Amomum longiligulare polysaccharides 1- PLGA nanoparticle and its immune enhancement ability on RAW264.7 cells [J]. International Immunopharmacology, 2021, 99, 108035.

4.Yongjian Zhu, Xiru Wang, Chenglong Zhang, Jiahao Ni, Qiyuan Luo, Ling Teng, Suya Liao, Yuhui Yang, Huricha Chen,Yun Chen*. Characterizations of glucose-rich polysaccharides from Amomum longiligulare T.L.Wu fruits and their effects on immunogenicities of infectious bursal disease virus VP2 protein [J]. International Journal of Biological Macromolecules, 2021, 183, 1574-1584.

5.Xin Yang, Shiwei Zhou, Hong Li, Jiangwen An, Chengheng Li, Ruigang Zhou, Ling Teng, Yongjian Zhu, Suya Liao, Yuhui Yang, Huricha Chen,Yun Chen*. Structural characterization of Alpiniae oxyphyllae fructus polysaccharide 2 and its activation effects on RAW264.7 macrophages [J]. International Immunopharmacology, 2021, 97, 107708.

6.Yun Chen*, Yu Zhang, Qiyuan Luo, Yongjian Zhu, Huijun Du, Suya Liao, Yuhui Yang, Huricha Chen. Inhibition of porcine epidemic diarrhea virus by Alpiniae oxyphyllae fructus polysaccharide 3 [J]. Research in Veterinary Science, 2021, 141, 146-155.

7.Yun Chen*, Qiyuan Luo, Shanman Li, Chengheng Li, Suya Liao, Xin Yang, Ruigang Zhou, Yongjian Zhu, Ling Teng, Huricha Chen, Yuhui Yang. Antiviral activity against porcine epidemic diarrhea virus of Pogostemon cablin polysaccharide [J]. Journal of Ethnopharmacology, 2020, 259, 113009.

8.Xin Yang, Yuhui Yang, Huricha Chen, Teng Xu, Chengheng Li, Ruigang Zhou, Linglin Gao, Mengmeng Han, Xiaotao He,Yun Chen*. Extraction, isolation, immunoregulatory activity, and characterization of Alpiniae oxyphyllae fructus polysaccharides [J]. International Journal of Biological Macromolecules, 2020, 155, 927–937.

9.Yun Chen, Ruigang Zhou, Lixing He, Fengyang Wang, Xin Yang, Ling Teng, Chengheng Li, Suya Liao, Yongjian Zhu, Yuhui Yang, Huricha Chen. Okra polysaccharide-2 plays a vital role on the activation of RAW264.7 cells by TLR2/4-mediated signal transduction pathways [J]. International Immunopharmacology, 2020, 86, 106708.

10.Yun Chen, Fangke Yao, Ke Ming, Jintong Shi, Ling Zeng, Deyun Wang, Yi Wu, Yuanliang Hu, Jiaguo Liu. Assessment of the Effect of Baicalin on Duck Virus Hepatitis [J]. Current Molecular Medicine, 2019, 19, 376-386.

11.Yun Chen, Yuhui Yang, Wenjuan Yuan, Zhaohui Wang, Ke Ming, Ling Zeng, Jiaguo Liu. Effects of Bush Sophora Root polysaccharide and its sulfate on DHAV-1 replication [J]. Carbohydrate Polymers, 2018,197: 508-514.

12.Yun Chen, Wenjuan Yuan, Yuhui Yang, Fangke Yao, Ke Ming, Jiaguo Liu. Inhibition mechanisms of baicalin and its phospholipid complex against DHAV-1 replication [J]. Poultry Science 2018, 97: 3816-3825.

13.Yun Chen, Yuhui Yang, Fengyang Wang, Xin Yang, Fangke Yao, Ke Ming, Wenjuan Yuan, Ling Zeng, Jiaguo Liu. Antiviral effect of baicalin phospholipid complex against duck hepatitis A virus type 1 [J]. Poultry Science, 2018, 97: 2722-2732.

14.Yun Chen, Ling Zeng, Yu Lu, Yulan Yang, Meiyun Xu, Yixuan Wang, Jiaguo Liu. Treatment effect of a flavonoid prescription on duck virus hepatitis by its hepatoprotective and antioxidative ability [J]. Pharmaceutical Biology, 2017, 55: 198-205.

15.Yun Chen, Ling Zeng, Jingjing Yang, Yixuan Wang, Fangke Yao, Yi Wu, Deyun Wang, Yuanliang Hu, Jiaguo Liu. Anti-DHAV-1 reproduction and immuno-regulatory effects of a flavonoid prescription on duck virus hepatitis [J]. Pharmaceutical Biology, 2017, 55: 1545-1552.

16.Yun Chen, Fangke Yao, Ke Ming, Deyun Wang, Yuanliang Hu, Jiaguo Liu. Polysaccharides from Traditional Chinese Medicines: Extraction, Purification, Modification, and Biological Activity [J]. Molecules, 2016, 21: 1705.

17.Yun Chen, Meiyun Song, Yixuan Wang, Wen Xiong, Ling Zeng, Shuaibing Zhang, Meiyun Xu, Hongxu Du, Jiaguo Liu, Deyun Wang, Yi Wu, Yuanliang Hu. The anti-DHAV activities of Astragalus polysaccharide and its sulfate compared with those of BSRPS and its sulfate [J]. Carbohydrate Polymers, 2015, 117: 339-345.

18.Yun Chen, Ling Zeng, Wen Xiong, Meiyun Song, Hongxu Du, Yixuan Wang, Ke Ming, Yi Wu, Deyun Wang, Yuanliang Hu, Jiaguo Liu. Anti-duck virus hepatitis mechanisms of Bush Sophora Root polysaccharide and its sulfate verified by intervention experiments [J]. Virus Research, 2015, 204: 58-67.

19.Yun Chen, Yi Wu, Luanting Xian, Meiyun Song, Ling Zeng, Wen Xiong, Jiaguo Liu, Weidong Sun, Deyun Wang, Yuanliang Hu. Effects of Bush Sophora Root polysaccharide and its sulfate on immuno-enhancing of the therapeutic DVH [J]. International Journal of Biological Macromolecules, 2015, 80: 217-224.

20.Yun Chen, Wen Xiong, Ling Zeng, Deyun Wang, Jiaguo Liu, Yi Wu, Yuanliang Hu. Comparison of Bush Sophora Root polysaccharide and its sulfate’s anti-duck hepatitis A virus activity and mechanism [J]. Carbohydrate Polymers, 2014, 102: 333-340.

21.Yun Chen, Wen Xiong, Ling Zeng, Yu Wang, Shuaibing Zhang, Meiyun Xu, Meiyun Song, Yixuan Wang, Hongxu Du, Jiaguo Liu, Deyun Wang, Yi Wu, Yuanliang Hu. Bush Sophora Root polysaccharide and its sulfate can scavenge free radicals resulted from duck virus hepatitis [J]. International Journal of Biological Macromolecules, 2014, 66: 186-193.

荣誉

海南大学“五一劳动之星”（2020）